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Matthew Hurst's avatar

Good Lord. Much as I love pre-prints, they can exacerbate this kind of thing. Peer review is maybe the worst of all systems for scientific debate, apart from all the others?

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Federico Soto del Alba's avatar

I don´t deny the irrationality of current statements passed as Medical and/or Scientific in the Discourse about Diseases by non experts, or qualified experts who talk nonsense.

But from my point of view, my experience and knowledge it seems to me the almost conclusion, to make a medical pun: the outcome, perhaps not the result? despite best efforts! of the History of Medicine and Medical non-research in the Past decades. (After all some patients get better even well despite treatment!, it happens!, who is to tell the difference?, hence the medical use of outcome and not result!, is lingo for as it happened more or less)

A lot fo drugs are withdrawn after reaching market for harmful side effects. Saying those are not detected in effectiveness trials on account of sample sizes does not take into account the over 90% withdrawal rates at least in one published study.

Nor it accounts for the lack of clear mechanism of action, the pharmacokinetics, nor the pharmacodynamical omissions in some subsamples. Nor the bias in selection of research subjects. Among other Pharma Trickery.

Nor it accounts for the invention of Diseases or the expansion of definitions of Diseases to larger and larger segments of population previously diagnosed as normal.

Nor the lack of published research in how to apply research results to unique patients. This last one was common when I was a med student decades ago. Specially when Drugs mechanisms were known for most drugs used then mixed with the physiopathology of unique patients.

Therapy by obscurity I think lead to this Fiasco, almost maddness, currently engulfing in irrational rhetoric to put it mildly. In great part, but I admit Therapy was not the only driving force.

And such is not the responsibility of the current buffoons like Bienveniste, the Canards, but the Clinical Researchers, Journals, Collegiate Bodies, Key Opinion Leaders, Law and it´s effects on Regulators like the FDA, etc. Among the ideological incentives and the probably not cost/effectiveness of most medical treatments for at least Chronic Diseases. Among others.

My point is there is History there, this Carnival of Buffoons did not started after the 2000s nor the 2010s...

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